Colloquium: “Epigenetic Inheritance from Yeast to Man: Molecular Memory Systems in Health and Disease” — January 20, 2022 at 4 PM
Oliver Rando, Ph.D.
Department of Biochemistry and Molecular Biotechnology
University of Massachusetts Medical School
Thursday, January 20, 2022, 4 PM
George P. Williams, Jr. Lecture Hall, (Olin 101)
Video Link will be available if needed
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A reception will be held outside Olin Building Entrance* at 3:30 PM prior to the colloquium. All interested persons are cordially invited to attend.
*Due to Covid restrictions, the university requires all food served and consumed outside. Inclement weather arrangements provided if needed.
In addition to the well-understood role for DNA as the central carrier for heritable information in biology on this planet, over the past few decades it has become clear that additional information can be passed from one generation to the next via so-called “epigenetic inheritance.” The Rando lab focuses on the How, What, and Why of epigenetic inheritance. I will discuss two areas of interest for our lab. In the first, I will describe our efforts to understand the polymer folding puzzle of how the genome is organized in 3-dimensional space, and how this folding affects the function of the genome. In the second, I will describe our studies on effects of a father’s diet and lifestyle on health and disease in offspring, and our attempts to address the question of how much information mammalian sperm carry.
Epigenomics and the structure of the living genome.
Friedman N, Rando OJ. Genome Res. 2015 Oct;25(10):1482-90. doi: 10.1101/gr.190165.115. PMID: 26430158
Transgenerational Epigenetic Inheritance.
Bošković A, Rando OJ. Annu Rev Genet. 2018 Nov 23;52:21-41. doi: 10.1146/annurev-genet-120417-031404. Epub 2018 Aug 30. PMID: 30160987