Colloquium: “Polymer Nanoparticles Rescue Vision in Blind Retinas” — October 14, 2021 at 4 PM
Guglielmo Lanzani, Ph.D.
Full Professor, Department of Physics, Politecnico di Milano, Italy
Researcher-Principal Investigator, Center Coordinator
Center for Nano Science and Technology
@PoliMi, Istituto Italiano di Tecnologia, Milano, Italy
George P. Williams, Jr. Lecture Hall, (Olin 101)
Thursday, October 14, 2021, at 4 PM
Video Link will be available if needed
To obtain the video conference link, contact firstname.lastname@example.org
Welcome back to in-person colloquia!
A reception will be held in Olin Lounge* at 3:30 PM prior to the colloquium. All interested persons are cordially invited to attend.
* We encourage all to wander out to the front entrance of the building or up to the Observatory Deck on the 3rd floor to enjoy their refreshments.
Organic semiconductors in different shapes and composition can be interfaced with living cells. This provides a new, exciting route towards optical control of physiological functions or the restoring of natural functions. In this talk I will present a number of experiments that show the effective abiotic-biotic coupling with cells and small animals, suggesting the potential of organic light actuators for geneless opto stimulation via soft interfaces. Investigated systems are based on carbon molecules or polymers as photoactive component in planar films, nanostructured layers or nanoparticles. Spectroscopy, photo-electrochemistry and photo-electrophysiology are exploited to carry out the experimental investigations. While the mechanism explaining such coupling is still unknown, it is appearing that thermal, capacitive, faradaic or chemical coupling are all options to be carefully evaluated.
To conclude the successful use of organic semiconductors for restoring visual acuity in blind animals will be reported [1,2].
 José Fernando Maya-Vetencourt et al. “A fully organic retinal prosthesis restores vision in a rat model of Degenerative blindness” Nature Materials 16, 681 (2017)
 José Fernando Maya-Vetencourt et al. “Subretinally injected semiconducting polymer nanoparticles rescue vision in a rat model of retinal dystrophy” Nature Nanotechnology 15, 698-708 (2020)
Chem. Soc. Rev., 2018 10.1039/C7CS00860K